MRB, Route 1070
Department of Microbiology & Immunology
Director of Cell Biology Core Laboratory, Department of Microbiology
NIEHS Center and Sealy Center for Environmental Health & Medicine
School of Medicine
Graduate School of Biomedical Sciences
|PhD | 1986 | Hungarian Academy of Science, Budapest, Hungary|
|MS | 1974 | University of Philosophical Sciences, Debrecen, Hungary|
|DM&B | 1974 | Medical University of Debrecen, Debrecen, Hungary|
|MS | 1970 | Lajos Kossuh University of Natural Sciences, Debrecen, Hungary|
Oxidative stress, mitochondrial abnormalities in in?ammation, and aging processes.
Dr. Boldogh’s program is centered on studies of oxidative stress, which, due to reactive oxygen species (ROS), is continuously generated during respiration, and is also induced by exogenous environmental pollutants. ROS is also generated endogenously by intracellular oxidases due to in? ammation, infections and drug treatment. Although a variety of cellular processes have evolved to eliminate ROS, oxidative stress occurs when there is an imbalance between production of ROS and antioxidant defense. hundreds to thousands of mitochondria are present in all eukaroytic cells perform multiple cellular functions, and are the major source of cellular energy and ROS. In mitochondria, ROS are formed by the univalent reduction of molecular oxygen mediated by respiratory complexes and via reactive compounds such as semi-ubiquinone. The long-term goal is to use multidisciplinary approaches to understand the basic mechanisms by which mitochondrial ROS augments airway in?ammation, etiological agents in aging, and how they cause age-associated diseases localized to the heart, lungs and central nervous system, induce mutations and promote tumor formation and progression.
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