Professor, Microbiology & Immunology and Pathology
Analysis of unique murine models of inflammatory bowel disease.
|Visiting PhD Student | 1988-1990 | Tufts University School of Medicine, Boston, MA|
|PhD | 1990 | Shandong University, P.R. China|
|MSc | 1985 | Shandong University, P.R. China|
|BSc | 1982 | Shandong University, P.R. China|
Dr. Yingzi Cong’s basic research program is based on the analysis of unique murine models of inflammatory bowel disease using a battery of reagents that have been developed recently. Our hypothesis is that IBD is mediated by a restricted set of pathogenic CD4+T cells responding to microbiota, the antigens to which the host is normally tolerant. Innate cells and TLR ligands play a critical role in activation and expansion of pathogenic T cells. microRNAs regulate host response to enteric bacterial antigens and pathogenesis of IBD. A number of research projects are underway in my laboratory and these NIH-funded studies involve a number of significant collaborations both at UTMB as well as with other Universities and Research Institutes. Specifically, individual projects include: