Faculty

Gary R. Klimpel, Ph.D.

Professor
gklimpel@utmb.edu
MRB, Route 1070
Department of Microbiology & Immunology
Phone: (409)772-4917
Fax: (409)747-6869

Education:

Ph.D. | 1976 | University of Arizona College of Medicine, Tucson, AZ

Overview

Immunology of leptospirosis and development of vaccines against bio-terrorist pathogens.

Research Interests

Two areas of immunobiology are investigated in Dr. Klimpel's laboratory. One is the study of how the human innate immune response is affected by Francisella tularensis, a select agent. This work involves investigating human monocytes, macrophages, natural killer cells, and dendritic cells. His lab is interested in comparing avirulent-versus-virulent bacteria. This work also investigates the bacterial components involved in activating the human innate immune response, as well as potential role of complement in this activation. He also explores potential vaccines using an animal model. A second project involves investigating the immunobiology of leptospirosis, a very problematic disease in underdeveloped countries, caused by a spirochete of the genus Leptospira. This is a collaborative project involving investigators in Peru and San Diego, CA. In this study, his lab is investigating both human innate immune and T cell memory responses. Finally, he has an ongoing interest in the human immune response to hepatitis C virus.

Recent Publications

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