MRB, Route 1070
Department of Microbiology & Immunology
|PhD | 1976 | University of Arizona College of Medicine, Tucson, AZ|
Immunology and vaccine development against Francisella tularensis, a select agent and potential bio-terrorist pathogen.
Dr. Klimpelís laboratory is studying how the human innate immune response is affected by Francisella tularensis, a select agent. This work involves investigating human monocytes, macrophages, natural killer cells, and dendritic cells. His lab is interested in comparing avirulent-versus-virulent bacteria. This work also investigates the bacterial components involved in activating the human innate immune response, as well as potential role of complement in this activation. He has also developed an animal model for investigating potential vaccines and for studying the role of antibody in immunity and host defense against this select agent.
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