Professor and Graduate Program Director
MRB, Route 1019
Department of Microbiology & Immunology
Phone: (409)772-5926 (lab) | (409)747-0395 (office)
|PhD | 1984 | University of Bern, Switzerland|
|MS | 1980 | University of Bern, Switzerland|
Signal transduction and activation in T lymphocytes; adaptive immunity to bacterial infections; systems biology (transcriptomics and proteomics) of inflammation and autoimmunity; immunotoxicology.
Research activities in Dr. König’s laboratory are aimed at elucidating the cellular and molecular mechanisms that regulate T lymphocyte signal transduction and activation. In current projects, we identify antigens formed by exposure to environmental chemicals, and investigate the in?ammatory responses and autoimmune diseases induced by these chemicals. Using transcriptomics, we determine the signal transduction pathways that are altered by environmental toxicants, leading to chronic inflammation, autoimmunity, and carcinogenesis. We also use proteomics to determine the effects of aging on T cell signaling.
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