MRB, Route 1019
Department of Microbiology & Immunology
Scientist, Sealy Center for Vaccine Development
Member, Center for Biodefense and Emerging Infectious Diseases
|PhD | 1992 | University of Georgia|
|MS | 1986 | Shanghai Medical University, PR China|
|MD | 1983 | Shanghai Medical University, PR China|
Protective immunity and pathogenesis of hepatitis C virus infection.
Dr. Sun's laboratory studies the immunological mechanisms of hepatitis C virus persistence and pathogenesis, and the effector mode of cytotoxic T cells in disease resolution or progression. Hepatitis C virus has an unusual ability to establish persistent infection in the majority of patients. The failure to clear the virus, despite relatively robust immune responses, suggests that the virus may have evolved some specific mechanisms of immune evasion. Using a hepatitis C transgenic mouse as a model, Dr. Sun is currently investigating how the virus may interfere with the ability of the immune system to clear the infection. He is attempting to understand how immune responses are regulated so that some lead to viral clearance, while others result in chronic inflammation of the liver. In addition, research efforts are directed at defining preventive strategies for the control of hepatitis C.
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