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Faculty

MinKyung Yi, PhDMinKyung Yi, PhD

Associate Professor, Microbiology & Immunology
Replication of hepatitis A virus and hepatitis C virus


miyi@utmb.edu
MRB 4.142H, Route 1019
Department of Microbiology & Immunology
Phone: (409) 772-2338
Fax: (409) 772-5065

Education:

PhD | 1997 | Cancer Research Institute, Kanazawa University, Japan
MS | 1992 | Pohang Institute of Science and Technology, Life Science, Korea
BS | 1990 | Seoul National Unversity, College of Pharmacy, Korea


Overview:
Replication of hepatitis A virus and hepatitis C virus

Research Interests

Hepatitis C virus is a small, enveloped, positive-stranded RNA virus belonging to the family Flaviviridae. The majority of cases of HCV infection become chronic, and HCV often leads to serious liver diseases, including chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV infection has also been linked to metabolic diseases, such as NAFLD (non alcoholic fatty liver disease) and type 2 diabetes. Our laboratory is involved in research to dissect the mechanism of HCV replication. Our current research focuses on three major areas. First, we are studying the role of viral nonstructural proteins in infectious particle formation. Second, we are interested in understanding the viral perturbation of the host lipoprotein synthesis pathway during viral egress. Third, we are interested in the mechanism of HCV- induced cytopathogenicity. We developed a cell culture infectious genotype 1a H77S strain that had been proven to cause chronic infection in a chimpanzee. We also have an access to a genotype 2a JFH1 strain which caused acute infection in the chimpanzees. Having both of these infectious clones of HCV gives us a major advantage in studying HCV replication and virus-host interaction.

Recent Publications

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