Students

Michelle H Nelson

Major: Immunology
Joined program in 2006

Mentor: Dr. Milligan
Awards/Grants: 2007-2008 Sealy Center for Vaccine Development Fellow
2007 Christina Fleischmann Scholarship

Publications/Experience:
1. Nelson MH, Stein DA, Kroeker AD, Hatlevig SA, Iversen PL, Moulton HM. Arginine- Rich Peptide Conjugation on Morpholino Oligomers: Effects on Antisense Activity and Specificity. Bioconjug Chem. 16: 959-966; 2005.
2. Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL. Cellular Uptake of Antisense Morpholino Oligomers Conjgated to Arginine-Rich Peptides. Bioconjug Chem. 15: 290-299; 2004.
3. Moulton HM, Hase MC, Smith KS, Iversen PL. HIV Tat Peptide Enhances Cellular Delivery of Antisense Morpholino Oligomers. Antisense Nucleic Acid Drug Dev. 13: 31-43; 2003.
4. Iversen, PL, Moulton HM. Nelson MH. Kroeker AD. Stein DA. Compositions for Enhancing Transport of Molecules Into Cells. Published Patent Application Number: 20040265879. 2004 Dec 30.

Research Description:
Research activities are aimed at investigating the adaptive immune system involved in resolving HSV-2 infection using a murine model. A current project involves characterizing the differences in proliferation, activation status and cytokine production of CD8+ T lymphocytes when generated in vitro in the absence of INF-γ. It has been demonstrated that there are two subsets, type 1 and type 2, which display opposing phenotypes. Elucidation of the ability of these two subsets’ to resolve primary viral infection is currently been studied. The second project is to understand the characteristics of the CD8+ T cell memory response elicited and promote those candidate vaccine strategies that generate memory responses needed for effective protection. It will involve looking at the homing and long-term memory of the CD8+ T cells in anogenital mucocutaneous sites and sensory ganglia.

Hometown: Portland OR
Education: Western Oregon University
Hobbies:: hiking
Contact: mhnelson@utmb.edu

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