Phone: (409) 772-2829
Education: PhD, 1993, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia
MS, 1984, Pyatigorsk Pharmaceutical Institute, Pyatigorsk, Russia
Overview: Filoviruses Ebola and Marburg: vaccines, antibodies, pathogenesis, anti-viral small molecules, and immune responses in bats.
Our group focuses on development of vaccines, antibody treatments
and small molecule treatments against filoviruses Ebola and Marburg and
on investigation of the mechanisms of their high pathogenicity. Our
research includes the following specific topics:
To get insight into these scientific topics, we are using
molecular tools, including reverse genetics (i.e. development of
genetically modified filoviruses from the DNA-copies of their genomes
and use of mini-genomes), immunological tools such as multi-parameter
flow cytometry, and human immune cells and animal models. Our research
includes experiments in a BSL-2 lab and in the BSL-4 labs of the
Galveston National Laboratory.Â
Our research is supported by multiple sources, including R01 and
multiple U19 grants from NIH, and grants from DTRA (DoD) and the
Department of Homeland Security.
Our collaborators include Dr. James Crowe, Jr. (Vanderbilt
University), Dr. Chris Basler (Mount Sinai), Dr. Sergei Nekhai (Howard
University), Dr. Thomas Geisbert (UTMB), Dr. Siba Samal (University of
Maryland), Dr. Scott Weaver (UTMB), Dr. Raul Andino (UCSF), and Dr.
Werner Braun (UTMB).
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