Alexander Bukreyev, PhDAlexander Bukreyev, PhD
Department of Pathology and Department of Microbiology & Immunology

Phone: (409) 772-2829

Education: PhD, 1993, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Russia
MS, 1984, Pyatigorsk Pharmaceutical Institute, Pyatigorsk, Russia

Filoviruses Ebola and Marburg: vaccines, antibodies, pathogenesis, anti-viral small molecules, and immune responses in bats. 

Research Interests

Our group focuses on development of vaccines, antibody treatments and small molecule treatments against filoviruses Ebola and Marburg and on investigation of the mechanisms of their high pathogenicity. Our research includes the following specific topics:

  • Characterization of antibody responses to filovirus infections in humans, in collaboration with Dr. James Crowe, Jr. (Vanderbilt University).
  • Development of therapeutic human monoclonal antibody treatments for filoviruses, in collaboration with Dr. James Crowe, Jr. (Vanderbilt University).
  • Development of mucosal respiratory tract vaccines against filoviruses based on human and non-human paramyxovirus vectors.
  • Investigation of mechanisms of “immune paralysis” caused by filoviruses.
  • Development of therapeutics targeting filoviral replication and interferon-antagonist functions (in collaboration with Dr. Sergei Nekhai and Dr. Chris Basler).
  • Comparative immunology of bats as a reservoir of filoviruses (in collaboration with Dr. Chris Basler).
  • Genome sequencing of emerging viral pathogens, including paramyxoviruses and filoviruses.

To get insight into these scientific topics, we are using molecular tools, including reverse genetics (i.e. development of genetically modified filoviruses from the DNA-copies of their genomes and use of mini-genomes), immunological tools such as multi-parameter flow cytometry, and human immune cells and animal models. Our research includes experiments in a BSL-2 lab and in the BSL-4 labs of the Galveston National Laboratory. 

Our research is supported by multiple sources, including R01 and multiple U19 grants from NIH, and grants from DTRA (DoD) and the Department of Homeland Security.

Our collaborators include Dr. James Crowe, Jr. (Vanderbilt University), Dr. Chris Basler (Mount Sinai), Dr. Sergei Nekhai (Howard University), Dr. Thomas Geisbert (UTMB), Dr. Siba Samal (University of Maryland), Dr. Scott Weaver (UTMB), Dr. Raul Andino (UCSF), and Dr. Werner Braun (UTMB).

Recent Publications

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