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Antonella Casola, MDAntonella Casola, MD
Professor
Departments of Pediatrics and Microbiology & Immunology


Phone: (409) 747-0581
Fax: (409) 772-1761
Email:
ancasola@utmb.edu

Education: MD, 1989, University of the Studies of Napoli, Italy
BS, 1983, Liceo Classico S. Orsola Benincasa, Napoli, Italy

Overview: RSV, hMPV

Research Interests

Dr. Casola’s research interests involve studies of virus-epithelial cell interactions as they relate to mucosal inflammation. In the past few years, she has been investigating how respiratory syncytialus (RSV) regulates CXC and CC chemokine expression in airway epithelial cells. These studies have used approaches to describe cis and trans control mechanisms in transcriptional regulation of these highly inducible genes. Dr. Casola’s laboratory is currently studying several inducible intracellular signaling pathways activated by RSV in airway epithelial cells with particular emphasis on the role of MAP kinases and reactive oxygen species in RSV induced lung inflammation both in vitro and in vivo, using a mouse model of RSV infection. Her laboratory has also initiated studies to investigate the pathogenesis of a newly identified respiratory virus, called human metapneumovirus (hMPV). They have developed a rodent model of infection and are currently testing the role of specific viral protein using recombinant hMPV, lacking the expression of single or multiple proteins, using in vitro and in vivo approaches.

Recent Publications

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