Barry Rockx, PhD
Departments of Pathology and Microbiology
PhD, 2004, Graduate School of Animal Health, Utrecht, The Netherlands
MSc, 1998, Vrije Universiteit, Amsterdam, The Netherlands
BS, 1997, Hogeschool West-Brabant, Etten-Leur, The Netherlands Overview:
Antigen processing; T-cell presentation; mucosal immunity; H.
pylori,inflammatory bowel disease, gastric cancer, peptic ulcer disease.
Dr. Rockx’s research interests are focused on virus-host
interactions,molecular pathogenic mechanisms, and the host responses
followingemerging high containment virus infection. His research will
focus onthe development and characterization of in vivo and in vitro
models ofHendra (HeV) and Nipah virus (NiV) infection. HeV and NiV are
twomembers of the genus Henipavirus (family Paramyxoviridea) that
causerespiratory illness and encephalitis in humans and a variety of
othermammals. The goal of these projects is to understand how these
virusesinfect the respiratory tract and spread to the central nervous
systemand to identify differences in routes of transmission and
pathogenesisbetween different HeV and NiV strains.
A second area of interest is the development and testing of
broadlyprotective therapeutics. The high mutation rate and heterogeneity
ofemerging zoonotic viruses is a major problem in developing
therapeuticsand therefore a key objective is the development of
broadlycross-reactive reagents that will maximize the likelihood of
protectionagainst unknown future strain variants.
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