MRB 4.134; 4.138Office Phone:
(409) 747-0395 Lab Phone:
Education: PhD, 2010, University of Pennsylvania Perelman School of Medicine
Overview: HIV/AIDS, RNA virus, Host-virus interactions, Antiviral Immunity, Epigenetics
Dr. Hu’s laboratory is interested in understanding host-virus
interactions and antiviral immunity for HIV/AIDS and infections caused
by RNA viruses. A long-term goal is to develop countermeasures to combat
these life-threatening viral diseases.
currently has three major research projects. The first project
investigates host epigenetic and transcriptional mechanisms regulating
HIV proviral transcription and latency, and develops novel strategies to
disrupt or enforce HIV latency. The lab also examines the effects of
these epigenetic and transcriptional machineries on regulating other
viral infections. The second project elucidates how antigen- or viral
vector-induced T cells are differentially infected and depleted by
HIV/SIV in AIDS pathogenesis (e.g. opportunistic and co-infections) and
immunization. The third project focuses on host-viral vector
interactions in vaccine development. We employ various model systems
(cell culture, animal models, and human clinical specimens) to
understand how viral vectors may modulate vaccine-induced innate and
adaptive immunity. Through collaboration with other laboratories, we are
interested in developing new vaccine approaches for HIV and emerging
Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure. Alamer E, Zhong C, Hajnik R, Soong L, Hu H. Retrovirology. 2021 Jan 7; 18 (1) :3 . PMCID: PMC7792063.
Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580. Alamer E, Zhong C, Liu Z, Niu Q, Long F, Guo L, Gelman BB, Soong L, Zhou J, Hu H. J Virol. 2020 May 18; 94 (11). PMCID: PMC7269428.
Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, Gelman BB, Tian B, Kim JH, Michael NL, Robb ML, Ananworanich J, Zhou J, Hu H. J Clin Invest. 2019 Jul 22; 129 (8) :3361-3373. PMCID: PMC6668673.
IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice. Liang Y, Yi P, Ru W, Jie Z, Wang H, Ghanayem T, Wang X, Alamer E, Liu J, Hu H, Soong L, Cai J, Sun J. J Neuroinflammation. 2020 Aug 25;17(1):249. PMCID: PMC7448338.
Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection.
Auclair S, Liu F, Niu Q, Hou W, Churchyard G, Morgan C, Frahm N, Nitayaphan S, Pitisuthithum P, Rerks-Ngarm S, Kimata JT, Soong L, Franchini G, Robb M, Kim J, Michael N, Hu H. PLoS Pathog. 2018 Feb; 14 (2) :e1006888. PMCID: PMC5841825.
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H. J Immunol. 2017 Nov 1; 199 (9) :3293-3305. PMCID: PMC5679316.
Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection. Liu F, Fan X, Auclair S, Ferguson M, Sun J, Soong L, Hou W, Redfield RR, Birx DL, Ratto-Kim S, Robb ML, Kim JH, Michael NL, Hu H. PLoS Pathog. 2016 Jun; 12 (6) :e1005663. PMCID: PMC4900544.
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals. Hu H, Eller MA, Zafar S, Zhou Y, Gu M, Wei Z, Currier JR, Marovich MA, Kibuuka HN, Bailer RT, Koup RA, Robb ML, Michael NL, Kim JH, Ratto-Kim S. Proc Natl Acad Sci U S A., 2014 Sep 16; 111 (37) :13439-44. PMCID: PMC4169982.
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