Oxidative stress, mitochondrial abnormalities in inflammation, and aging processes

Dr. Boldogh’s program is centered on studies of oxidative stress, which, due to reactive oxygen species (ROS), is continuously generated during respiration, and is also induced by exogenous environmental pollutants. ROS is also generated endogenously by intracellular oxidases due to inflammation, infections and drug treatment. Although a variety of cellular processes have evolved to eliminate ROS, oxidative stress occurs when there is an imbalance between production of ROS and antioxidant defense. hundreds to thousands of mitochondria are present in all eukaroytic cells perform multiple cellular functions, and are the major source of cellular energy and ROS. In mitochondria, ROS are formed by the univalent reduction of molecular oxygen mediated by respiratory complexes and via reactive compounds such as semi-ubiquinone. The long-term goal is to use multidisciplinary approaches to understand the basic mechanisms by which mitochondrial ROS augments airway inflammation, etiological agents in aging, and how they cause age-associated diseases localized to the heart, lungs and central nervous system, induce mutations and promote tumor formation and progression.

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