Janice Endsley, PhD
Departments of Microbiology & Immunology and PathologyPhone:
(409) 772-3142 Fax:
(409) 772-6869Email: firstname.lastname@example.org
BS, 1992, University of Wisconsin-Platteville
PhD, 2000, Iowa State University
Overview: TB and TB/HIV co-infection, cell mediated immunity and signal transduction
My research is focused on mechanisms and regulation of cell mediated immunity to Mycobacterium tuberculosis (M.tb).
We utilize human subjects, infected human lung tissue, and mouse and
humanized mouse models of experimental tuberculosis (TB) for these
studies. An important component of my work is investigations to
determine how human immunodeficiency virus (HIV) compromises CD8+T cell
and macrophage function in the host immune response to M.tb.
The goal of these basic studies is to identify mechanisms whereby the
CD8+T cell subset can be targeted by vaccine adjuvants and/or
antigens. Additionally, I have NIH funding to develop the humanized
mouse as a small animal model of HIV/M.tb co-infection.
Development of this model will greatly enhance capabilities to design
and screen innovative prophylactics and therapeutics for TB to use in
populations with HIV-compromised immune systems. Through collaboration
I have additionally extended my studies of cytotoxic lymphocytes to
include natural killer cell function in infectious disease (M.tb, B. anthracis) and reproduction.
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