Sanjiv Sur, MD
Departments of Internal Medicine, Allergy, Asthma and Microbiology & Immunology
MD, 1983, Medical College, Kanpur, India
MBBS, 1980, Medical College, Kanpur University Kanpur, IndiaOverview:
Allergic sensitization and asthma using molecular biology tools, role of genes in asthma.
Dr. Sur will pursue the hypothesis is that reactive oxygen species
(ROS) generated by interaction of intrinsic NADPH oxidases in pollens
with NADPH in airway lining fluid provides a critical second signal
that activates MAP kinases and induces of expression of genes in the
lungs that augment mucin production, airway inflammation and AHR in
allergic asthma. Three specific aims are proposed:
- Activation of MAP kinases by Signal 2 mediates induction of
genes and gene products that facilitate trafficking of dendritic and
Th2-cells and augment mucin production in airway epithelial cells.
- Elevated levels of 4-HNE and GSSG in the lungs directly
potentiate airway inflammation, AHR and mucin production in naÃ¯ve
mice, and induce specific genomic signatures in the lungs.
- MAP kinases regulate subsets of Signal 2-sensitive global genomic signature in lungs.
This project will define the molecular mechanisms of signal
2-induced pathways and will fundamentally shift our understanding of
the mechanisms of initiation of allergic inflammation in asthma from a
one-signal paradigm to a novel two-signal pathway.
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