Teh-sheng Chan, MD, PhD
Department of Microbiology & Immunology
Fax: (409) 772-5065
1969, Yale University, New Haven, Connecticut
MD, 1963, National Taiwan University, College of Medicine, Taipei, Taiwan
Overview: Transgenic mouse model for hepatitis C; asthma research using a mouse model; gene therapy.
Pathogenesis and antiviral therapy of severe acute respiratory syndrome (SARS).
Among Dr. Chan's research interests is the mechanism of immunodeficiency and asthma. His lab has derived a conditional adenosine deaminase knockout mouse which manifests in immunodeficiency syndrome and asthma. Using microarray and proteomic strategies,
Dr. Chan's research group is investigating the mechanism of immunodeficiency and asthma pathogenesis. Another interest is in the immunopathogenesis of hepatitis C. His lab has derived transgenic lines conditionally expressing hepatitis C virus structural
or non-structural proteins, using cre-lox technology. These mouse lines are especially suitable for Dr. Chan's investigation of the host immune response to viral proteins, with an emphasis on the host-virus interaction in the innate immune response.
Yet another project involves a SARS transgenic mouse model. Based on the hypothesis that SARS coronavirus tropism is determined by the surface receptor for the virus, the group has successfully derived transgenic lines which support active virus replication
in mice that develop signs of respiratory insufficiency that mimic SARS. His lab is using these mouse lines to investigate SARS pathogenesis, and to develop effective antivirals and vaccines against the disease.
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