Teh-sheng Chan, MD, PhD
Department of Microbiology & Immunology
PhD, 1969, Yale University, New Haven, Connecticut
MD, 1963, National Taiwan University, College of Medicine, Taipei, Taiwan
Overview: Transgenic mouse model for hepatitis C; asthma research using a mouse model; gene therapy.
Pathogenesis and antiviral therapy of severe acute respiratory syndrome (SARS).
Among Dr. Chan's research interests is the mechanism of
immunodeficiency and asthma. His lab has derived a conditional
adenosine deaminase knockout mouse which manifests in immunodeficiency
syndrome and asthma. Using microarray and proteomic strategies, Dr.
Chan's research group is investigating the mechanism of
immunodeficiency and asthma pathogenesis. Another interest is in the
immunopathogenesis of hepatitis C. His lab has derived transgenic
lines conditionally expressing hepatitis C virus structural or
non-structural proteins, using cre-lox technology. These mouse lines
are especially suitable for Dr. Chan's investigation of the host
immune response to viral proteins, with an emphasis on the host-virus
interaction in the innate immune response. Yet another project
involves a SARS transgenic mouse model. Based on the hypothesis that
SARS coronavirus tropism is determined by the surface receptor for the
virus, the group has successfully derived transgenic lines which
support active virus replication in mice that develop signs of
respiratory insufficiency that mimic SARS. His lab is using these mouse
lines to investigate SARS pathogenesis, and to develop effective
antivirals and vaccines against the disease.
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