Vladimir Motin, PhDProfessor
Departments of Pathology and Microbiology & Immunology
Phone: (409) 772-3155
Email: vlmotin@utmb.eduEducation: PhD, 1988, Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, USSR
BS, 1983, Institute for Engineering and Physics, Moscow, USSR
Overview: Bacterial Pathogenesis, Systems Biology, Host Defense and Immunity, Diagnostics, Therapeutics and Vaccines.
Research Interests
Currently, my major research interest is the pathogenesis of
Yersinia pestis, the etiological agent of plague. Although plague is not
a public heath problem in most parts of the world, its potential for
contagion, the lack of an effective vaccine, and the recent emergence of
multiple antibiotic resistance strains place this organism squarely at
the top of the United States’ select agent list as a potential candidate
for bioterrorism use. The long-term goal of my research is to elucidate
the molecular mechanisms that underlie the nature of the acute
bacterial infectious process caused by Y. pestis. The identification of
the environmental signals that the bacteria encounter in the host cells
and the potential virulence genes regulated by those signals will lead
to a better understanding of the process of cross-talk between pathogen
and its host during the infection. The unraveling of the Y. pestis
virulence network will allow us to determine novel targets for
therapeutics beyond antibiotics, to generate new vaccines and develop
robust diagnostic assays.
Recent Publications
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