Required and Offered Courses » Advanced Immunology (MICR 6048)

Spring 2018

Dates: January 4, 2018 - April 20, 2018 (Tuesdays & Thursdays)
Times: 9:00-11:00 am (unless otherwise noted)
Room: MRB 4.145 (unless otherwise noted)
Course Number: MICR 6408

Course Directors

Janice Endsley, PhD | Ext. 23142 | Rm. 3.142 MRB
Gregg N. Milligan, PhD | Ext. 78145 | Rm. 3.322 MMNP

Course Coordinator: Aneth Zertuche | Ext. 22322 | Fax: 25065 | Rm. 4.102 MRB

Textbook and Reading Materials

There is no required textbook for this course. For each lecture, instructors will provide background reading, usually in the form of review articles and a current research manuscript from the immunology literature. These materials will be sent to students a week in advance of the lecture. Students should come to class prepared to discuss relevant materials.

Course DescriptionView on GSBS website

Advanced Immunology is designed to provide the basic scientist with an enhanced understanding of immunological concepts and techniques applicable to research in immunology and related fields. Specifically, the goal is to familiarize students with the current immunological concepts, paradigms, and techniques that are applicable not only to research in immunology but are also increasingly necessary for an enhanced understanding of all biological disciplines.

The course will be offered in the spring semester and taught by a number of expert lecturers. Advanced Immunology will be taught in lecture format (2 hr/lecture; 2 lectures/week), which will include classical didactic experiences, instructor-guided discussions of relevant scientific literature, and student-led discussions of cutting-edge topics in immunology. Additionally, students will give oral presentations, approximately 30 minutes in length, on selected topics in Immunology. A list of topics appropriate for presentations will be provided by the Course Directors at the beginning of the course.

Course Objectives

The Advanced Immunology course is intended for graduate-level students to build upon a basic level of understanding of the immune system. The topics that will be covered include: innate and acquired immune responses; cellular and molecular mechanisms of immunity; antigen processing and presentation; tissue-specific immune responses; immune-mediated pathologies; and vaccination. The primary objective is to provide the basic scientist with an enhanced understanding of immunological concepts that are relevant to a wide range of biological fields.

Additional exercises that are structured to promote self-learning and critical evaluation skills include:

  1. Student-lead mini-lectures on immunological tools and techniques will enhance student understanding of basic concepts in immunology, the experimental approaches that can be taken to address immunological problems, and an improved ability to understand and critically evaluate immunological literature
  2. Instructor-guided, student-lead discussions of relevant scientific literature will promote the students' ability to critically evaluate scientific literature and their ability to design meaningful experiments
  3. Student familiarity with the immunological literature and self-learning are enhanced through inclusion of student-selected and student-lead discussions of cutting-edge topics in immunology and through a more extended and thorough oral presentation of selected topics in Immunology. Student presentation skills and critical evaluation skills are enhanced in these exercises through evaluations provided by both course directors and student peers.

Grades

Three exams will be given over the duration of the course on the dates indicated on the course schedule. All exams will be of the essay type and will be taken in class. The exams will comprise 75% of the final grade (25% each). Oral presentations and class participation will comprise 25% of the final grade.

Make-up tests will only be allowed in emergency situations which preclude the student from physically being present. Emergency situations are defined as incapacitating illnesses or family emergencies. There will be no deviation from this policy.

Any appeals for grading changes must be submitted to the lecturers responsible for the writing and grading of the questions within one (1) week after the return of the graded examination to the student. The lecturers must report changes in grades to the Course Directors.

Final course letter grades will be determined using the following grading scale:

  • 90-100 = A
  • 80-89 = B
  • 70-79 = C
  • 69 or below = F

Course Evaluation

Students will also be required to complete an evaluation form about the course as part of their overall course grade. Typically, your constructive comments are in exchange for your graded exams. If the specified number of evaluation forms is not received, an Incomplete grade will be reported to the Office of Enrollment Services. If the course requirements are not completed within 30 days, the grade automatically converts to an 'F' Failure grade.

 Any appeals for grading changes must be submitted to the instructors responsible for the writing and grading of the question within five (5) business days after the return of the graded assessment to the student. The instructors must report any grade changes to the Course Directors.

Excused Absences

The GSBS policy states that students taking a full-term graduate course offering are allowed up to three (3) excused absences from any required activity and permission is granted at the discretion of the Course Directors. If the course is offered as an 8-week course, only two (2) absences are permitted. If a student is absent during a session that contributes to the final grade (e.g., during a quiz), it will be up to the Course Directors to determine if the student can perform a "make-up" activity, provided that they deem absence legitimate. Once a student exceeds and misses more than the number of absences allowed for the length of the course, the course directors must notify the GSBS Student Affairs Dean, who will then contact the appropriate Program Director.

Professional Etiquette

Courtesy should be extended to both the lecturers and students to ensure an optimal learning atmosphere. Students are expected to come to class prepared, ready to participate, and on time. Students will not be allowed to enter the room once the lecture has begun. To ensure an environment for constructive academic dialogue, the use of electronic devices (e.g., laptops, cell phones, MP3 players) is not allowed during class time. Please request permission from each lecturer prior to electronic recording of lectures.


Course Schedule

ClassDateInstructorTopic
11/4/18Gregg Milligan, PhDClass Overview
Immune System Overview
(no paper discussion)
21/9/18Janice Endsley, PhDEvolution of the Immune System
(paper discussion)
31/11/18Tina Wang, PhDNK Cells and γδ T cells
(paper discussion)
31/16/18TBAMonocytes & Macrophages in Infection
(paper discussion)
51/18/18Lynn Soong, MD, PhDCytokines and Chemokines
(paper discussion)
61/23/18Janice Endsley, PhD
Greg Milligan, PhD
Student Presentations
Immunologic Tools
(student presentations / no paper discussion)
71/25/18Lynn Soong, MD, PhDNeutrophils in Host Defense
(paper discussion)
81/30/18Victor Reyes, PhDAntigen Processing & Lymphocyte Diversity
(paper discussion)
 2/1/18
8:00-12:00
EXAM I
(Proctor: Dr. Milligan)
Topics #2 - #8
(exclude #6)
92/6/18Paper Discussion by Students
Facilitator: Gregg Milligan, PhD
102/8/18Lynn Soong, MD, PhDDendritic Cells
(paper discussion)
112/13/18Ricardo Rajsbaum, PhDType I Interferons 
(paper discussion)
122/15/18Jiaren Sun, MD, PhDT Cell Development & Activation
(paper discussion)
132/20/18Yingzi Cong, PhDAutoimmunity & T Cell Tolerance
(paper discussion)
142/22/18Nigel Bourne, PhDVaccine Development
(paper discussion)
152/27/18Gregg Milligan, PhDB Cell Activation, Function & Memory
(paper discussion)
 3/1/18
8:30a-12:30p
EXAM II
(Proctor: Dr. Endsley)
Topics #10 - #15
163/6/18Janice Endsley, PhD
Gregg Milligan, PhD
Tina Wang, PhD
Hot Topics in Immunology
173/8/18Haito Hu, PhDImmunology of HIV and Immune suppression
183/13/18Paper Discussion by Students
Facilitator: Janice Endsley, PhD
193/15/18Yingzi Cong, PhDMucosal Immunology
(paper discussion)
203/20/18Robin Stephens, PhDMemory T Cells
(paper discussion)
213/22/18Tracy Toliver-Kinsky, PhDImmunological Responses to Trauma
(paper discussion)
223/27/18Janice Endsley, PhDLung Immune Responses
(paper discussion)
233/29/18Jiaren Sun, MD, PhDLiver Immune Responses
(paper discussion)
244/3/18Mini lectures by fellowsTopics to be confirmed
(“Innate Recognition”)
254/5/18Mini lectures by fellowsTopics to be confirmed
(“Innate Recognition”)
264/10/18Mini lectures by fellowsTopics to be confirmed
(“Acquired Immunity”)
274/12/18Mini lectures by fellowsTopics to be confirmed
(“Acquired Immunity”)
 4/19/18
8:30a-12:30p
EXAM III
(Proctor: Dr. Milligan)
Topics #17 - #23

Last Class Day: 4/20/18
Grades Due: 4/27/19
Monday Holidays: 1/15 and 2/19
Dates/times subject to change. Last revised 12/6/17